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Tofisopam is a popular anxiolytic medication and is mainly used for anxiety and alcohol-withdrawal. It is available as Tofisopam 50mg and 100mg tablets and needs to be taken within doses of 50-300mg thrice daily, not exceeding beyond 12 weeks. Instead of branded ones, you can also go for generic cheap Tofisopam tablets. Moreover, It is very simple and quick to buy Tofisopam online (without prescription) and from over the counter with a physician’s prescription.
What is Tofisopam?
Tofisopam is a popular anxiolytic medication used mostly in European countries. It belongs to the 2,3 benzodiazepine group of medications. But unlike other Benzodiazepines, it does not have anti-convulsant, skeletomuscular relaxant, amnestic properties and produces sedation only in higher doses. Its functions are chiefly directed towards the treatment of anxiety and alcohol withdrawal. Tofisopam tablets make use of a lower tolerance rate, unlike other benzodiazepines, and can be prescribed up to 12 weeks. It is marketed under the brand name of Emandaxin and Grandaxin. Tofisopam was first synthesized in Hungary in 1966 and has been a popular anti-anxiety medication since the 1970s. Apart from the United States and Canada, it is available for use in all countries.
What is Tofisopam used for?
Doctors will recommend you to Tofisopam dosage for anxiety and alcohol withdrawal (a set of symptoms like anxiety, shakiness, and increased heart rate that occur on reducing the intake of alcohol after a period of excessive use). It is also used to treat irritable bowel syndrome, i.e., a gastrointestinal condition leading to abdominal pain and inconsistent bowel movements. The therapeutic effects of Tofisopam have led to it being called a PDE Inhibitor and discussed for being used in the treatment of Schizophrenia. Reports of Tofisopam having uricosuric effects have been researched, making it a potential medication in Gout patients’ treatment. Recently Tofisopam has also been a topic of discussion regarding its use in Covid positive patients to provide neuropsychiatric relief.
How Does Tofisopam Work on the Body?
Tofisopam is a unique 2,3 benzodiazepine medication in the group of CNS active compounds. Benzodiazepines are a class of medications used to treat anxiety and have sedative and muscle relaxation properties. 2, 3 benzodiazepines and 1,4 benzodiazepines are benzodiazepine derivatives. A benzodiazepine derivative is an active compound that has some of the qualities of Benzodiazepines but is not totally like benzodiazepines. Tofisopam works by increasing the action of the GABA chemical messenger that suppresses the abnormal and excessive activity of the nerve cells in the brain. But unlike other derivatives, it does not bind to the benzodiazepine binding site. This causes its pharmacological properties to be different from that of others. Along with these, Tofisopam acts as a selective inhibitor of the phosphodiesterases helping in the treatment of psychosis.
How to Buy Tofisopam in the USA?
You can order Tofisopam branded as well as generic versions. At the same time, the branded versions are prescription medications and available only in a physician’s office or in pharmacies after availing a prescription. However, you can buy generic or cheap Tofisopam online or over the counter. It is very simple and quick to buy Tofisopam online. But it is important to check the site’s authenticity before purchasing, along with checking the products and package post-delivery to rule out chances of pilferage.
What is Generic Tofisopam?
Generic versions are nothing but cheap Tofisopam tablets that contain almost the same ingredients as branded Tofisopam but are more economical and more readily available than branded versions. Branded Tofisopam is not readily available and needs a physician’s prescription for procuring it. But generic Tofisopam can be easily obtained under the counter along with being available online. The effects of generic Tofisopam are slightly less than its branded version, but the difference is minimal. Toficalm and Nextril are some of the popular generic versions of the medications available in 50mg doses. They come in strips of 10 medications. Additionally, Tofiel, Tofinsin, Tofis, Trondheim, and Tsurubel are some of the other generic names of the medications available in other countries. These medications are used primarily for the treatment of anxiety and secondarily for alcohol withdrawal and other purposes.
How do you Take Tofisopam Tablets?
It is available as Tofisopam 50mg and 100mg tablets. It is supposed to be taken within doses of 50-300mg thrice daily, not exceeding beyond 12 weeks. It has not yet been researched for use in children and thus should never be given to children along with keeping it out of their reach. Tofisopam should be swallowed whole with a glass full of water, either with or without food. It should not be broken or crushed before use as that can increase its activity, leading to overdose symptoms. It starts working within 30-60 minutes of being consumed and has a peak effect within 1-2 hours. Tofisopam has a relatively short half-life of 6-7 hours, after which it is metabolized by the liver and released through urination. Once started, the medication should not be stopped abruptly or without the advice of the practitioner. If you have missed a dose, don’t overdose to make up for the missed dose.
What are the Side Effects Associated with the use of Tofisopam?
Constipation, headache, allergic reaction and muscle pain are some of the common side-effects associated with use of Tofisopam. Fever, dry mouth, skin rashes and drowsiness are other complications that can ensue with prolonged use of the medication. Insomnia, increased irritability and agitation can also occur on overusing the medication. Sometimes, obstructive jaundice and increased flatus may be associated with its consumption. Rarely, respiratory depression may occur coupled with epileptic seizures, confusion and even coma with its overuse.
What are the Precautions that need to be taken while using Tofisopam?
Alcohol and nicotine should be avoided at all cost as they can decrease the metabolism of Tofisopam and in the process impact its effectiveness. If you stop the medication suddenly, it may lead to a number of complications like nausea, anxiety, agitation, flu-like symptoms and confusion. Additionally, Tofisopam should never be used in respiratory disorders, glaucoma or seizures as it can further worsen the condition. It is important to note that Tofizospam has a tendency to cause sleep disorders because of which it is best to use it in the evening so its effects gradually start working by night. If the sleeping disorders continue, it is advisable to discontinue Tofisopam to reduce the risk of further problems.
What Care Should Be Taken in Using Tofisopam?
Constipation, headache, allergic reaction, and muscle pain are some of the common side-effects associated with the use of Tofisopam. But Lifestyle habits like alcohol and nicotine can decrease the metabolism of Tofisopam and, in the process, impact its effectiveness. Drugs like Ketoconazole and Itraconazole may produce the opposite reaction, i.e., inhibit its metabolism, causing it to accumulate an increased concentration in the blood plasma. Similarly, antacids, antihypertensives, and oral contraceptives may affect the metabolism or absorption of the medication, making it important to be cautious before combining the medication. It is important to note that suddenly stopping the medication instead of tapering the doses may lead to several complications like nausea, anxiety, agitation, flu-like symptoms, and confusion. Additionally, Tofisopam should never be used in respiratory disorders, glaucoma, or seizures, and they can cause further worsening of the condition.
What are the Drug Interactions of Tofisopam?
Tofisopam should not be used in combination with immunosuppressants like cyclosporine and tacrolimus medications as they are metabolized by the liver enzymes and using them together can increase their concentration in blood plasma leading to overdosing symptoms. Similar effects are produced by antifungals like ketoconazole and Itraconazole with oral contraceptives used in combination with Tofisopam because of which caution should be exercised. Research has proved that essentially CNS suppressants like analgesics, antihistamines, antidepressants, sedatives and hypnotics tend to cause drowsiness along with respiratory depression when taken together with Tofisopam.